Wastewater-based epidemiology in countries with poor wastewater treatment – Epidemiological indicator function of SARS-CoV-2 RNA in surface waters폐수 처리가 열악한 국가의 폐수 기반 역학 - 지표수에서 SARS-CoV-2 RNA의 역학 지표 기능Article Published on 2022-10-152022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, 치료제, [키워드] adaptation adoption affected alternative analysed applied approach Bacteria Belgrade collected complex complex systems Concentration country COVID-19 Danube effort epidemiological epidemiological purposes Epidemiology Factor Factors Faecal pollution Genes Genetic human populations identify indicated methodology N1 and N2 nucleocapsid outbreak parameter physicochemical primer set primer sets Protein qualitative data quantification quantified Quantitative recipient river RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 surveillance Sava Serbia surface Surface waters Surveillance Treatment Untreated wastewaters. Volume water [DOI] 10.1016/j.scitotenv.2022.156964 PMC 바로가기 [Article Type] Article
Inhibition of major histocompatibility complex-I antigen presentation by sarbecovirus ORF7a proteinsArticle Published on 2022-10-112022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] absence acute respiratory syndrome Affect Amino acid Antigen Antigen presentation biological activity caused CD8 Cell complex Coronavirus-2 Cytotoxic T cells dissemination down-regulation downregulating Endoplasmic reticulum expressed histocompatibility complex human populations immune responses Immunity induce infected with SARS-CoV-2 Infection inhibited inhibition mechanism MHC-I MHC-I down-regulation ORF7a orf7a protein peptide Peptide loading complex persistence physically prevented reduced sarbecovirus sarbecovirus Sarbecovirus. SARS-CoV SARS-CoV-2 T cells variety viral peptide Viral proteins [DOI] 10.1073/pnas.2209042119 PMC 바로가기
Allelic Variations in the Human Genes TMPRSS2 and CCR5, and the Resistance to Viral Infection by SARS-CoV-2인간 유전자 TMPRSS2 및 CCR5의 대립형질 변이와 SARS-CoV-2에 의한 바이러스 감염에 대한 내성Article Published on 2022-08-152022-09-11 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, [키워드] addition age allelic variant allelic variants analyzed CCR5 CCR5 gene Clinical course close contact Comorbidities Comorbidity conditions contact with correlation COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 infection demonstrated described determinant Disease progression disease severity Europe explain First wave Gender Genetic polymorphism genetic variability highest Human human genes human populations identify Italy life cycle male mortality rate mortality rates old age performed polymorphism predisposition progression resistance rs12329760 rs333 rs35074065. SARS-CoV-2 SARS-CoV-2 first wave infection SARS-COV-2 infection SARS-CoV-2 viral Sicily subject subjects TMPRSS2 TMPRSS2 gene viral infection virus virus infection with COVID-19 [DOI] 10.3390/ijms23169171 PMC 바로가기 [Article Type] Article
A strategy to assess spillover risk of bat SARS-related coronaviruses in Southeast Asia Research Published on 2022-08-092022-10-05 Journal: Nature Communications [Category] SARS, 치료기술, [키워드] antibody Asia bat-CoV can be used caused Contact coronavirus COVID-19 disease distribution Health help Host human populations infect median MERS overlap risk SARS-related coronavirus SARSr-CoV SARSr-CoVs Surveillance virus zoonotic spillover [DOI] 10.1038/s41467-022-31860-w [Article Type] Research
No molecular evidence of SARS-CoV-2 infection in companion animals from Veracruz, Mexico멕시코 베라크루즈의 반려동물에서 SARS-CoV-2 감염의 분자적 증거 없음Article Published on 2022-07-012022-09-11 Journal: Transboundary and emerging diseases [Category] COVID19(2023년), SARS, 치료기술, [키워드] Active surveillance acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach cats Chain Reaction close contact collected coronavirus coronavirus COVID-19 detect dogs epidemiological epidemiological surveillance Evidence exposure to human populations imperative infectious agent infectious agents Latin America limit measure molecular N1 and N2 Nasopharyngeal swab nasopharyngeal swab sample oral organism Organisms pathogen Pathogens patients with COVID-19 polymerase chain polymerase chain reaction Population Prevent qPCR recent reduce reverse transcription reverse transcription polymerase chain reaction risk of transmission RNA RT-qPCR SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus shown species Surveillance susceptible tested Total total RNA Transmission Transmission dynamics transmitted viral gene viral genes viral infection Viral infection. was performed [DOI] 10.1111/tbed.14153 PMC 바로가기 [Article Type] Article
Broadly recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles널리 알려진 교차 반응성 SARS-CoV-2 CD4 T 세포 에피토프는 인간 코로나바이러스 전반에 걸쳐 고도로 보존되어 있으며 일반적인 HLA 대립유전자에 의해 제시됩니다Article Published on 2022-06-142022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Affect animal coronavirus binding CD4 CD4 T cell CD4 T cells common-cold conserved Contact convalescent COVID-19 CP: Immunology CP: Microbiology cross-reactive cross-reactivity Donor donors driven by epitope explained fusion peptide Heterologous heterologous immunity highlight HLA allele homology human coronavirus human populations Infection major histocompatibility complex memory response MHC class mRNA vaccine overlapping preference Protein proximal raise recipients residue SARS-CoV-2 SARS-CoV-2 sequence seasonal coronavirus spike fusion peptide proximal region. Substitution T cell T cell epitope T cell receptor T cell receptor repertoire T cell response TCR TCR sequencing TCRs uninfected [DOI] 10.1016/j.celrep.2022.110952 PMC 바로가기 [Article Type] Article
Natural SARS-CoV-2 Infection in a Free-Ranging Black-Tailed Marmoset (Mico melanurus) from an Urban Area in Mid-West Brazil브라질 중서부 도시 지역의 자유 범위 검은꼬리 마모셋(Mico melanurus)에서 자연적인 SARS-CoV-2 감염Article Published on 2022-06-012022-09-11 Journal: Journal of comparative pathology [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] alveolar septa animal Antigen Area Black-Tailed Marmoset Brazil clinical history COVID-19 female Hepatitis Host human populations immunohistochemistry Interstitial nephritis intestine large intestine liver lung lung tissue Lymph node Lymphocytes lymphoid marmoset Mild motor vehicle nasopharyngeal natural natural infection necropsy New World New World monkey nodule one health oropharyngeal swab pathogen Pathogens peribronchial periportal platyrrhines. Polytrauma pool Protein risk SARS-CoV-2 SARS-COV-2 infection Spike protein spleen state the viral nucleocapsid urban urban area viral nucleocapsid protein Viral RNA viral RNA detection [DOI] 10.1016/j.jcpa.2022.03.005 PMC 바로가기 [Article Type] Article
Experimental Infection of Mink with SARS-COV-2 Omicron Variant and Subsequent Clinical DiseaseSARS-COV-2 오미크론 변이체에 의한 밍크의 실험적 감염 및 후속 임상 질환Article Published on 2022-06-012022-09-11 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus 2 American mink animals changes clinical Clinical sign Clinical signs coronavirus coronavirus disease COVID-19 Finland human populations Infection mink models omicron positive recipients respiratory infections SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread uninfected variant Viral RNA virus viruses zoonoses zoonoses. [DOI] 10.3201/eid2806.220328 PMC 바로가기 [Article Type] Article
Spread of Gamma (P.1) Sub-Lineages Carrying Spike Mutations Close to the Furin Cleavage Site and Deletions in the N-Terminal Domain Drives Ongoing Transmission of SARS-CoV-2 in Amazonas, Brazil브라질 아마조나스에서 SARS-CoV-2의 지속적인 전파를 유도하는 N-터미널 도메인의 삭제 및 푸린 절단 부위에 가까운 스파이크 돌연변이를 운반하는 감마(P.1) 하위 계통의 확산Research Article Published on 2022-02-232022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, [키워드] affected analyzed antibody binding affinity Brazil Carrying concern coronavirus COVID-19 COVID-19 epidemic COVID-19 vaccines Ct value declined declining Deletion deletions diagnosed domain drive driven by driver Drivers effort Endemic ENhance evade Evidence Evolution of SARS-CoV-2 expected furin furin cleavage site Gamma genomic Genomic surveillance hosts human population human populations Immunity incidence increase in individual Lineage lineages Local mandatory molecular molecular dynamics Mutation N-terminal natural infection neutralizing antibody NTD number of infected P.1 P681H Pandemics parental Patient positive Prevalence reduce reveal risk S1/S2 junction SARS-CoV-2 SARS-CoV-2 genomic surveillance second wave significantly Site spike Spread Still subjects suggested Support Surveillance susceptible susceptible hosts the binding affinity the median the SARS-CoV-2 transmission of SARS-CoV-2 triggered vaccination vaccine breakthrough infections Vaccines variant variant gamma variants Viral Virus evolution viruses VoC Whole-genome sequence Δ144 [DOI] 10.1128/spectrum.02366-21 PMC 바로가기 [Article Type] Research Article
Experimental Models of COVID-19COVID-19의 실험 모델Review Published on 2022-01-052022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 진단, [키워드] in vitro model ACE2 receptor African African green monkeys animal model animal models balancing biosafety level cell line contribute COVID-19 COVID-19 disease different cell different cells Epidemic experimental models of COVID-19 ferret green hamster Hepatitis Human human populations humanized immortalized In-vitro Infection Laboratory level 3 macaques mechanism MHV-1 mice mimicking Model mouse mouse hepatitis murine hepatitis virus NHPs non-human primates pandemic pathology Pneumonia Prevent primate receptor receptors Replication Research rhesus macaques robustness SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection Scientific community Spectrum susceptible therapy Transgenic mouse Transmission transmitted treat variants of concern Viral viral infection virus [DOI] 10.3389/fcimb.2021.792584 PMC 바로가기 [Article Type] Review